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为研究青岛地区乙型肝炎病毒（ＨＢＶ）母婴垂直传播情况，对１２１例母亲是ＨＢＶ无症状携带者的高危新生儿生后２４小时之内采周围静脉血监测ＨＢＶ标志物与母亲ＨＢＶ标志物进行对照分析，结果表明，新生儿ＨＢｓＡｇ、ＨＢｅＡｇ、ＨＢｃＡｂ有一项阳性者８８例，ＨＢＶ感染率为７２７％（８８／１２１）。母亲ＨＢｓＡｇ、ＨＢｅＡｂ、ＨＢｃＡｂ三项均阳性者２４例，所生新生儿ＨＢＶ一项阳性者２２例，感染率为９１６％（２２／２４）。提示母婴垂直传播是新生儿ＨＢＶ感染的重要途径，特别是ＨＢｓＡｇ、ＨＢｅＡｇ、ＨＢｃＡｂ均阳性的母亲，其新生儿ＨＢＶ感染率最高，阻断ＨＢＶ母婴传播意义重大。
In order to study the vertical transmission of hepatitis B virus (HBV) in infants and young children in Qingdao area, peripheral blood was collected from peripheral blood of 121 high-risk neonates whose mothers were asymptomatic carriers of HBV within 24 hours after birth to detect HBV markers and maternal HBV markers The control analysis showed that there were 88 positive cases of HBsAg, HBeAg and HBcAb in neonates, and the HBV infection rate was 72.7% (88/121). Twenty-four mothers were positive for HBsAg, HBeAb and HBcAb. Twenty-two newborns were born with HBV infection. The infection rate was 91.6% (22/24). Prompted the vertical transmission of mother and baby is an important way of neonatal HBV infection, especially HBsAg, HBeAg, HBcAb positive mothers, the highest HBV infection rate of newborns, blocking the mother-to-child transmission of HBV is of great significance.