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70年代Ｓｉｍｏｎｓ等相继报道ＨＬＡ Ａ2抗原与新加坡华人鼻咽癌相关[1] ,但对中国大陆不同地域的多次血清学分型调查均未发现ＨＬＡ Ａ2与鼻咽癌之间存在关联[2 4 ] 。由于ＨＬＡ Ａ2等位基因存在种族和地域差异 ,应用基因分型技术可以更准确地揭示ＨＬＡ Ａ2与鼻咽癌遗传易
In the 1970s, Simons et al reported that HLA A2 antigen was associated with nasopharyngeal carcinoma in Singapore [1], but no association between HLA A2 and nasopharyngeal carcinoma was found in multiple serological typing surveys in different regions of mainland China [24] . Due to race and geographical differences in the HLA A2 allele, genotyping can more accurately reveal the genetic predisposition of HLA A2 and NPC