系统性红斑狼疮 (systemiclupuserythematosus,SLE)是一种与遗传、环境、内分泌和免疫系统紊乱等多种因素有关的自身免疫性疾病 ,但到目前为止其确切病因和发病机制仍不清楚[1 ] 。HLA DM基因是 2 0世纪 90年代初新发现的位于HLA D区的一种非典型HLA Ⅱ类基因 ,其编码的DM分子 Systemic lupus erythematosus (systemic lupus erythematosus, SLE) is a genetic and environmental, endocrine and immune system disorders and other factors related to autoimmune diseases, but so far the exact etiology and pathogenesis remains unclear [1]. HLA-DM gene is an atypical HLA class II gene newly found in the HLA-D region in the early 1990s and encodes DM molecules