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目的研究内皮素-1(ET-1)在手足口病病情变化中的作用及常规临床检验在不同分型手足口病的意义。方法选取2010年4月至2010年11月住院的手足口病患儿40例,分为普通组,重症组和危重症组。记录患儿的临床资料,并通过酶联免疫定量检测血清ET-1水平。结果重症组和危重症组均较普通组血白细胞计数明显升高;危重症组较普通组血血糖水平明显升高;与重症组相比较,危重症组年龄偏小,血糖水平偏高。普通组、重症组和危重症组ET-1水平无统计学差异,但均高于正常水平。结论血白细胞和血糖是手足口病的病情的早期判断的重要辅助指标,年龄亦为危重症的危险因素之一,内皮素-1水平在手足口病患儿中会有所升高。
Objective To investigate the role of endothelin-1 (ET-1) in the pathogenesis of HFMD and the significance of routine clinical tests in HFMD. Methods Forty HFMD children admitted to hospital from April 2010 to November 2010 were selected and divided into general group, severe group and critically ill group. The clinical data of children were recorded and the level of serum ET-1 was detected quantitatively by enzyme-linked immunosorbent assay. Results Compared with the control group, the blood count of the critically ill group and the critically ill group were significantly higher than those of the common group. The blood glucose level of the critically ill group was significantly higher than that of the common group. Compared with the severe group, the critically ill group was younger and the blood glucose level was higher. The levels of ET-1 in normal group, severe group and critical illness group were not statistically different, but both were higher than the normal level. Conclusions Blood leukocyte and blood glucose are important auxiliary indicators for early judgment of HFMD. Age is also one of the risk factors for critically ill patients. The level of endothelin - 1 may be increased in HFMD children.