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目的:检验单胺氧化酶A(MAOA)基因启动子区域可变重复序列(VNTR)多态性与应激性生活事件对青少年外化性问题预测作用。方法:随机抽取湖南省长沙市某高中的224名学生,鉴定其MAOA基因型,分别用青少年生活事件问卷(ALEQ)与长处和困难问卷(SDQ)每隔三个月对被试的生活事件和外化性问题进行评估,共8次。运用多层线性模型对收集的数据进行统计分析。结果:1生活事件对男性和女性的外化性问题均有显著的预测作用(男性:B=0.040,P<0.001;女性:B=0.020,P<0.001)。2MAOA基因对男性和女性的外化性问题预测作用均无主效应(男性:B=0.064,P>0.05;女性:B=-0.080,P>0.05)。3女性样本中,MAOA基因与生活事件有显著的交互效应(B=-0.030,P<0.001),即经历同等程度的生活事件后,携带低活性基因型的女性比携带高活性基因型的女性个体更容易表现出外化性问题;男性样本中,MAOA基因与生活事件无显著的交互作用(B=0.005,P>0.05)。结论:MAOA基因对青少年的外化性问题无预测作用;MAOA基因与应激的交互作用能够预测女性青少年的外化性问题,而对男性青少年的外化性问题无预测作用。
OBJECTIVE: To test the predictive value of VNTR polymorphism and stress-induced life events (MAO) gene promoter polymorphisms on adolescent externalization. Methods: A total of 224 students from a high school in Changsha City of Hunan Province were selected to identify their MAOA genotype. The ALEQ and DSQ questionnaires were used to assess the life events and Evaluation of externalities, a total of 8 times. Use the multi-layer linear model to carry on the statistical analysis to the collected data. Results: 1 Life events had significant predictive effects on the externalization of both men and women (male: B = 0.040, P <0.001; female: B = 0.020, P <0.001). 2MAOA gene had no effect on the predictive effect of male and female externalization (male: B = 0.064, P> 0.05; female: B = -0.080, P> 0.05). In the 3 female samples, there was a significant interaction effect between MAOA gene and life events (B = -0.030, P <0.001). After the same level of life events, the women with low activity genotype had a significantly lower frequency than the women with high activity genotype Individuals were more likely to show the problem of externalization; there was no significant interaction between the MAOA gene and life events in the male sample (B = 0.005, P> 0.05). CONCLUSION: The MAOA gene has no predictive effect on the externalization of adolescents. The interaction between MAOA gene and stress can predict the externalization of female adolescents, but not the externalization of male adolescents.