评价了聚乙烯醇(PVA)作为黏膜黏附聚合物在直接压片法制备吲哚美辛黏膜黏附口颊片中的可用性。采用不同聚合度和粒径的PVA制备口颊片,并考察其拉伸强度、体外黏附力和吸水性。结果显示含中等黏度、小粒径PVA的片剂具有最大的拉伸强度。通过析因设计分析法优化得到了PVA的规格参数,用该优化PVA以直接压片法制备黏膜黏附口颊片,并与采用羧乙烯基聚合物和羟丙纤维素为黏膜黏附聚合物制备的口颊片进行 The applicability of polyvinyl alcohol (PVA) as mucoadhesive polymer in the preparation of indomethacin mucoadhesion buccal tablets by direct compression was evaluated. Preparation of buccal tablets with PVA of different polymerization degree and particle size and their tensile strength, in vitro adhesion and water absorption were investigated. The results show that tablets containing medium viscosity, small particle size PVA have the greatest tensile strength. The design parameters of PVA were optimized by factorial design and analysis. The mucoadhesion buccal tablets were prepared by the direct compression method with this optimized PVA and were prepared with carboxyvinyl polymer and hydroxypropylcellulose as mucoadhesive polymers Buccal tablets