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目的对50例单独应用左乙拉西坦(LEV)的癫癎患者进行临床观察和随访,以评估左乙拉西坦治疗各型癫癎的疗效和安全性。方法采用开放性自身对照方法对2009年6月~2010年3月本院及其门诊就诊的50例左乙拉西坦单药治疗的癫癎患者进行随访研究,收集治疗前后患者发作频率变化、发作情况、不良反应以及退出原因。其随访均在半年以上。结果 LEV单药治疗后癫癎发作完全控制率48%,有效率38%;其中部分性发作完全控制率40.9%,有效率45.5%;全面性发作完全控制率53.6%,有效率32.1%,对west综合症亦有效。不良反应包括情绪异常、易激惹12%(6/50),头晕8%(4/50),白细胞减少2%(1/50);上述不良反应均为一过性,在2~5周内自然消失,未导致停药,未发现过敏以及肝、肾功能异常等严重不良反应。结论 LEV是一种安全有效的抗癫癎药物,对部分性和全面性发作均有效,且安全耐受性较好。
Objective To evaluate the efficacy and safety of levetiracetam in the treatment of various types of epilepsy in 50 epileptic patients with levetiracetam (LEV) alone. Methods Fifty patients with levofloxacin monotherapy for treatment of epilepsy from June 2009 to March 2010 in our hospital and their outpatient department were followed up. The changes of seizure frequency before and after treatment were collected. Seizures, adverse reactions, and reasons for withdrawal. Their follow-up were more than six months. Results The complete control rate of epileptic seizures after LEV monotherapy was 48% and the effective rate was 38%. The complete control rate of partial seizures was 40.9% and the effective rate was 45.5%. The complete seizure complete control rate was 53.6% and the effective rate was 32.1% West syndrome is also effective. Adverse reactions included abnormal mood, irritability 12% (6/50), dizziness 8% (4/50) and leucopenia 2% (1/50). The above adverse reactions were transient. After 2-5 weeks Within the natural disappearance, did not lead to withdrawal, did not find allergies and liver, renal dysfunction and other serious adverse reactions. Conclusion LEV is a safe and effective anti-epileptic drug, which is effective in partial and comprehensive attacks and has good safety tolerance.