高亲和力、同种型转换过的抗体是机体长效抵抗微生物感染、维持自身健康的重要机制之一。抗体成熟过程发生在次级淋巴器官中一个主要由活化B细胞组成的特殊区域,称之为生发中心(germinal center,GC)[1-2]。生发中心反应是B细胞向记忆性细胞和骨髓中长期存活的浆细胞分化的重要选择阶段,而这两群B细胞对于迅速的体液免疫反应都是 High-affinity, isotype-converted antibodies are one of the important mechanisms for long-term resistance to microbial infections and their own health. Antibody maturation occurs in a special region of the secondary lymphoid organ that is primarily composed of activated B cells called the germinal center (GC) [1-2]. The germinal center response is an important selection phase for B cells to differentiate into long-term viable plasma cells in memory cells and bone marrow, both of which respond rapidly to humoral immune responses