目的全面掌握中国人“食管黏膜剥脱症”的临床特征及发病规律,以提高对本病的认识水平。方法以“食管剥脱”、“剥脱性食管炎”、“食管管型”、“食管黏膜血肿”为关键词,检索《中国期刊全文数据库》1979~2005年(模糊匹配)的近26年文献,相关论文全文下载,逐篇阅读,核对内容,将重复报道的病例资料予以合并,登记临床资料,最后进行归并、分析,并将我院诊治的1例病人资料也纳入研究。结果共检出136例病人,其中有个人资料者78例,综合资料者58例;男77例,女59例(男女之比1∶0.77);年龄6~82岁,以20~60岁占多;115例为平素健康人群(85.3%),急起发病;113例中109例有诱因;主要临床症状有咽喉及胸骨后疼痛或不适123例,呕吐、呕血118例,呕吐管型111例,由诱因到管型吐出的时间≤4 h者46例中有41例(89%);急诊内镜检查55例,黏膜剥脱、缺失伴创面出血为主者43例,以食管黏膜血肿为主12例;病理结果:80例病人共作了81次剥脱黏膜的病理检查,80%以上为非炎性;预后:治愈134例,死亡2例,随访80例,均无后遗症,内镜随访47例,食管黏膜短期修复,无粘连或狭窄。结论“食管黏膜剥脱症”好发于中青年无基础疾病的人群,性别差异不明显,几乎都有诱因,但有时诱因甚轻微,发病急,以咽喉及胸骨后疼痛、呕吐、呕血、呕吐管型为主要临床症状,急诊内镜可见黏膜剥脱、缺失伴创面出血或黏膜血肿,剥脱黏膜绝大多数为非炎性,治愈率高,无后遗症。 Objective To comprehensively grasp the clinical features and pathogenesis of Chinese esophageal mucosal exfoliation to improve the level of awareness of this disease. Methods With the key words of “esophageal exfoliation”, “esophageal exfoliation”, “esophageal tube type” and “esophageal mucosa hematoma”, we searched the nearly 26 years literature of “Chinese Journal Full-text Database” from 1979 to 2005 (fuzzy matching) Relevant papers were downloaded in full, read each article, check the content, will repeat the reported case information to be merged, registration of clinical data, the final merger, analysis, and hospital treatment of 1 patient data are also included in the study. Results A total of 136 patients were detected, including 78 cases with personal data and 58 cases with comprehensive data. There were 77 males and 59 females (the ratio of male to female was 1: 0.77). The age ranged from 6 to 82 years and ranged from 20 to 60 years 115 cases were normal healthy population (85.3%), acute onset; 113 cases were induced in 109 cases; the main clinical symptoms of throat and sternum pain or discomfort in 123 cases, vomiting, hematemesis in 118 cases, vomiting tube type in 111 cases , 41 cases (89%) of the 46 cases were induced by the inducement to the tube type discharge in 55 cases; the emergency endoscopy 55 cases, mucosal exfoliation and missing wounds with bleeding in 43 cases, mainly esophageal mucosal hematoma 12 cases; pathological results: 80 cases of patients with a total of 81 exfoliative mucosa pathology, more than 80% of non-inflammatory; prognosis: 134 cases were cured, 2 died, followed up 80 cases, no sequelae, endoscopic follow-up 47 Cases, esophageal mucosa short-term repair, no adhesions or stenosis. Conclusions Esophageal mucosal exfoliation occurs in young people without underlying diseases. There is no obvious gender difference. Almost all have incentives, but sometimes the causes are very slight. The incidence of acute esophageal mucosal exfoliation depends on the throat and sternal pain, vomiting, vomiting, vomiting Type as the main clinical symptoms, emergency endoscopic mucosal exfoliation, loss of wound or mucosal hematoma, mucosal exfoliation most of the non-inflammatory, high cure rate, no sequelae.