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目的研究短期雾霾暴露对成人系统性炎症的影响,并观察橙汁干预效果。方法在2015年11月至12月雾霾空气污染天气频发期间,将22名大学生自愿者随机分为雾霾暴露组和橙汁干预组(每天中午和晚上分别给予橙汁200m L),连续3周记录和评估两组自愿者的雾霾暴露水平,并测定实验开始前和暴露3周后的血细胞计数、血中各种炎症标志物水平。结果暴露开始前,两组自愿者的血细胞计数、血清炎性标志物差异均无统计学意义(P>0.05);连续暴露3周后,与暴露前相比雾霾暴露组和橙汁干预组自愿者血中白细胞计数、淋巴细胞百分数等无明显差异(P>0.05),但血清炎性标志物水平hsCRP明显高于暴露前(P<0.05),并且橙汁干预组血中血清炎性标志物hs-CRP水平均明显低于雾霾暴露组,差异有统计学意义(P<0.05)。结论短期雾霾暴露能明显增加人体的炎症标志物水平,并且橙汁干预能显著改善雾霾暴露所致炎性标志物升高状况。
Objective To study the effect of short-term smog exposure on adult systemic inflammation and to observe the effect of orange juice intervention. Methods Twenty-two college students volunteers were randomly divided into haze exposure group and orange juice intervention group (200m L of orange juice was given at noon and at night each day) during the haze air pollution weather from November to December in 2015. The volunteers were divided into three groups The level of haze exposure was recorded and evaluated for both groups of volunteers, and the blood counts before and 3 weeks after exposure were measured, and the levels of various inflammatory markers in the blood were measured. Results Before the start of the experiment, there were no significant differences in the blood count and serum inflammatory markers between the two groups (P> 0.05). After three weeks of continuous exposure, the volunteers in the two groups had no significant difference (P> 0.05). However, the level of serum inflammatory marker hsCRP was significantly higher than that before exposure (P <0.05), and the levels of serum inflammatory markers hs -CRP levels were significantly lower than the haze exposure group, the difference was statistically significant (P <0.05). Conclusion Short-term smog exposure can significantly increase the levels of inflammatory markers in human body, and orange juice intervention can significantly improve the elevated inflammatory markers caused by haze exposure.