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丙型肝炎病毒(hepatitis C virus,HCV)感染呈全球性流行,其最主要的特点是容易慢性化,且病情难以自行缓解。HCV慢性感染可导致肝脏慢性炎症坏死和进行性纤维化。活化的肝星状细胞和基质金属蛋白酶组织抑制因子-1(tissue inhibitors ofmetallopro-teinase-1,TIMP-1)在肝纤维化的
Hepatitis C virus (HCV) infection is a global epidemic. Its main feature is its easy to be chronic and difficult to relieve itself. Chronic HCV infection can lead to chronic liver inflammation necrosis and progressive fibrosis. Activated hepatic stellate cells and tissue inhibitors of metalloproteinase-1 (TIMP-1) in hepatic fibrosis