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在碳酸氢钠存在下，用一步法以苯并咪唑、甲醛、盐酸羟胺为原料，合成了N，N-双-（苯并咪唑基甲基）羟胺（Ⅰ）；苯并咪唑、甲醛与甲胺在甲苯溶液中回流分水，得到N，N-双-（苯并咪唑基甲基）甲胺（Ⅱ）．用N，N-双-（苯并咪唑基甲基）羟胺与格氏试剂反应合成了4个N，N-双取代羟胺（Ⅲ）．用N，N-双-（苯并咪唑基甲基）羟胺与丙烯酸甲酯、丙烯酸乙酯或反-丁烯二酸二乙酯发生1，3-偶极环加成反应，得到2－（苯并咪唑基甲基）异唑啉-5-羧酸酯或2-（苯并咪唑基甲基）异唑啉-4，5-二羧酸酯．用IR，1HNMR和元素分析确定了它们的结构．
In the presence of sodium bicarbonate, N, N-bis- (benzimidazolylmethyl) hydroxylamine (I) was synthesized by one-step method using benzimidazole, formaldehyde and hydroxylamine hydrochloride as raw materials; benzimidazole, The amine was separated by refluxing in toluene solution to give N, N-bis- (benzimidazolylmethyl) methylamine (II). Four N, N-disubstituted hydroxylamines (Ⅲ) were synthesized by the reaction of Grignard reagent with N, N-bis- (benzimidazolylmethyl) hydroxylamine. 1,3-Dipolar cycloaddition of N, N-bis- (benzimidazolylmethyl) hydroxylamine with methyl acrylate, ethyl acrylate or diethyl-butenedioate affords 2- ( Benzimidazolylmethyl) isoxazoline-5-carboxylate or 2- (benzimidazolylmethyl) isoxazoline-4,5-dicarboxylate. Their structures were confirmed by IR, 1HNMR and elemental analysis.