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目的:探讨2型糖尿病(2diabetes mellitus,T2DM)患者血糖控制水平与血清CA19-9的相关性。方法:化学发光法测定T2DM患者(A组,120例)及非糖尿病患者(B组,108例)的血清CA19-9水平。2组均排除其它可能导致CA19-9水平升高的常见疾病。按糖化血红蛋白水平将A组分为血糖控制组(A1组,58例,HbA1c≤7.0%)和非控制组(A2组,62例,HbA1c>7.0%)。统计软件SPSS17.0对各组进行组间对比分析,对可能影响CA19-9水平与T2DM的相关因素进行单因素相关分析及多元逐步回归分析。结果:组间对比分析结果显示,A组血清CA19-9水平显著高于B组(P<0.01);A1组与A2组比,A1组血清CA19-9水平低于A2组(P<0.01)。单因素相关分析显示,血清CA19-9水平与糖化血红蛋白(P<0.05)、糖尿病病程(P<0.05)存在相关性。多元逐步回归分析发现血清CA19-9水平与患者糖化血红蛋白呈线性相关。结论:血清CA19-9升高与T2DM存在相关性,可作为血糖控制水平的参考指标之一。
Objective: To investigate the correlation between blood glucose level and serum CA19-9 in patients with type 2 diabetes mellitus (T2DM). Methods: The level of serum CA19-9 in T2DM patients (A group, 120 cases) and non-diabetic patients (B group, 108 cases) was determined by chemiluminescence method. Both groups excluded other common diseases that could cause elevated CA19-9 levels. Group A was divided into glycemic control group (A1 group, 58 cases, HbA1c≤7.0%) and non-control group (A2 group, 62 cases, HbA1c> 7.0%) according to HbA1c level. Statistical software SPSS17.0 for each group comparative analysis between groups, the factors that may affect the level of CA19-9 and T2DM single factor correlation analysis and multiple stepwise regression analysis. Results: The results of comparative analysis between groups showed that the level of serum CA19-9 in group A was significantly higher than that in group B (P <0.01). The level of serum CA19-9 in group A1 was lower than that in group A2 (P <0.01) . Univariate correlation analysis showed that there was a correlation between serum CA19-9 level and glycosylated hemoglobin (P <0.05) and duration of diabetes (P <0.05). Multiple stepwise regression analysis found a linear correlation between serum CA19-9 level and HbA1c in patients. Conclusion: There is a correlation between elevated serum CA19-9 and T2DM, which may be used as a reference index for the control of blood glucose level.