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作者应用特异性猪脾转移因子(S-TF)治疗流行性出血热早期患者33例,与正常猪脾转移因子治疗组31例和安慰剂组35例比较,S-TF可显著促进病情转轻(与安慰剂组比较转轻率从5.7％增至27.3％),提高越期率(自74.3％至93.9％),减轻外渗和出血,缩短低血压时间(自5.67±11.80h至0.75±2.00h),并可增强细胞免疫功能(PHA皮试阳转率从8.7％增至47.7％),抑制抗体生成反应(血清IgG从16.1×10~3mg/L降至14.0×10~3mg/L,IgM从2.6×10~3mg/L降至1.8×10~3mg/L),但是对肾脏功能和血小板的损伤无明显改善。
In the early stage of treatment of 33 patients with epidemic hemorrhagic fever with specific swine transfer factor (S-TF), S-TF significantly improved the progression of the disease compared with 31 cases of spleen transfer factor-treated group and 35 cases of placebo group (Increased from 5.7% to 27.3% in the placebo group), increasing the overdraft rate (from 74.3% to 93.9%), reducing extravasation and bleeding, and shortening the duration of hypotension (5.67 ± 11.80 h to 0.75 ± 2.00 h), and enhanced cellular immune function (PHA skin test positive rate increased from 8.7% to 47.7%), inhibition of antibody production reaction (serum IgG from 16.1 × 10-3mg / L to 14.0 × 10-3mg / L, IgM from 2.6 × 10 ~ 3mg / L to 1.8 × 10 ~ 3mg / L), but no significant improvement on renal function and platelet damage.