目的 :研究钒及其化合物对哺乳动物雄性生殖细胞的致突变性。方法 :本研究选用雄性小鼠 ,用五氧化二钒溶液进行亚急性腹腔注射染毒。剂量为 0 .17mg/kg、2 .13mg/kg、6 .40mg/kg。观察初级精母细胞染色体畸变和早期精细胞微核率。 结果 :三受试组的初级精母细胞染色体畸变率依次为 1.4%、2 .6 % (P <0 .0 5 )、4.2 % (P <0 .0 5 ) ,有剂量反应关系 ,早期精细胞微核率依次为 2 .80‰、4.0 0‰、(P <0 .0 5 )、7.8‰ (P <0 .0 5 ) ,也有剂量反应关系。结论 :研究表明 ,五氧化二钒对哺乳动物雄性生殖细胞具有致突变性。 Objective: To study the mutagenicity of vanadium and its compounds on mammalian male germ cells. Methods: In this study, male mice were selected and sub-acute intraperitoneal injection of vanadium pentoxide solution was used. The dose was 0.17mg / kg, 2.13mg / kg, 6.40mg / kg. To observe the primary spermatocyte chromosome aberration and early sperm micronucleus rate. Results: The chromosome aberration rates of primary spermatocytes in the three test groups were 1.4%, 2.6% (P <0.05) and 4.2% (P <0.05), respectively. The dose-response relationship, The rates of micronuclei were 2.80 ‰, 4.0 ‰, (P <0.05), 7.8 ‰ (P <0.05), and also the dose-response relationship. CONCLUSIONS: Studies have shown that vanadium pentoxide is mutagenic to mammalian male germ cells.