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为探讨围体外循环期（ＰＣＰＢ）血浆内皮素（ＰＥＴ）与肾素（ＰＲＡ）、血管紧张素Ⅱ（ＡＮＧⅡ）、醛固酮（ＡＬＤ）的变化及关系，研究了三组肺循环压力不同（以右室流出道压代表循环压力，分为轻、中度肺循环压力升高组，压力分别为４～８ｋＰａ、８～１２ｋＰａ，记为ｍＰＰ及ＭＰＰ组及肺循环压力降低组，记为ＤＰＰ组）。结果表明：ＰＥＴ在ＣＰＢ期间均降低，以ｍＰＰ组最著；术后均升高，以ＭＰＰ为著，组间差异均有显著性（Ｐ＜０．０５）。ＰＲＡ在ＣＰＢ期升高明显，以ｍＰＰ组最著；术后降低，但仍高于术前，以ＭＰＰ组为著，组间差异均有显著性（Ｐ＜０．０１）。ＡＮＧⅡ、ＡＬＤ的变化趋势同ＰＲＡ。相关分析表明：ＤＰＰ组在ＣＰＢ３０ｍｉｎ、术后１２ｈ、２４ｈ，ＰＥＴ与ＰＲＡ间均呈显著正相关（ｒ及Ｐ依次为０．７７，＜０．０５；０．７６，＜０．０５；０．８２，＜０．０１），ＰＥＴ与ＡＮＧⅡ在术后１２ｈ、２４ｈ亦呈显著正相关（ｒ及Ｐ依次为０．７８，＜０．０５；０．８９，＜０．０１），在ＭＰＰ组ＰＥＴ与尿量在ＣＰＢ期间呈显著负相关（ｒ＝－０．８０，Ｐ＜０．０１）。ＰＥＴ与术后引流量之间三组病人均无明确相关关系。推测先天性心脏病人ＰＣＰＢ期ＰＥＴ与Ｒ?
To investigate the changes of plasma endothelin (PET) and renin (PRA), angiotensin Ⅱ (ANGⅡ) and aldosterone (ALD) during the cardiopulmonary bypass (PCPB) Outflow channel pressure on behalf of the circulatory pressure, divided into light and moderate pulmonary pressure group, the pressure was 4 ~ 8kPa, 8 ~ 12kPa, recorded as mPP and MPP group and pulmonary pressure reduction group, recorded as DPP group). The results showed that: PET decreased during CPB, with mPP group the most; postoperative were elevated, with MPP as the significant difference between the two groups (P <0.05). PRA increased significantly in CPB stage, the most in mPP group; decreased after operation, but still higher than preoperative, as in MPP group, there was significant difference between groups (P <0.01). ANG Ⅱ, ALD trend with PRA. Correlation analysis showed that there was a significant positive correlation between PET and PRA at DPP30min, 12h, 24h after PCI (r = 0.77, <0.05; 0.76, <0.05; 82, <0.01). There was also a significant positive correlation between PET and ANGⅡ at 12h and 24h after operation (r and P were 0.78, <0.05; 0.89, <0.01) There was a significant negative correlation between PET and urine volume during CPB (r = -0.80, P <0.01). PET and postoperative drainage volume between the three groups of patients no clear correlation. Conjecture congenital heart disease PCPB PET and R?