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目的 了解系统性红斑狼疮(SLE)患者外周血循环内皮细胞(CEC)的数量及其临床意义。方法采用密度梯度离心法检测45例SLE患者和30例正常人的血液标本。结果SLE患者和正常人的CEC数量分别是(7.8±4.2)×106/L、(3.7±1.1)×106/L，两者之间的差异有高度显著性(P<0.01)；活动期患者的CEC数量高于非活动期患者(P<0.01)SLE患者CEC数量与病情积分呈正相关(r=0.3817.P<0.05)。结论SLE患者的CEC数量升高，测定CEC数量对判断SLE患者的病情活动程度有帮助。“,”Objective To investigate the number of CEC in peripheral blood of patients with systemic lupus erythe-matosus (SLE) and its clinical significance. Methods The sample of blood from 45 cases opf SLE and 30 healthy con-trois were measured by density gradient centrifugal assay. Results The CEC number of SLE patients and the controlswere (7.8±4.2)×106/L and (3.7±1.1)×106/L respectively with significant difference (P＜0. 01). The CEC num-ber in active SLE was more than that in inactive SLE (P＜0. 01). There was a positive correlation between CEC num-ber and activity scores of SLE. Conclusion Increase of CEC can be found in SLE patients, and the measurement ofCEC number is helpful to the judgement of activity condition of the patients with SLE.