目的应用经阴道超声评估化疗致闭经患者卵巢的结构及血流动力学特点,为临床综合治疗提供重要的参考信息。方法化疗致闭经的乳腺癌术后患者48例,在化疗前,化疗6个疗程结束及化疗一年后,分别应用经阴道超声检查卵巢,包括卵巢大小、窦卵泡计数,卵巢间质血流动力学。同时检测血清雌二醇水平。结果卵巢体积比较:化疗前与化疗一年后比较,差异有统计学意义,化疗结束与化疗一年后比较,差异有统计学意义;窦卵泡计数比较:三个时间段差异均有统计学意义;卵巢间质动脉PSV(peakinssystolic velocity,收缩期峰值流速)及RI(resistance index,阻力指数)比较:化疗前与化疗一年后比较,差异有统计学意义,化疗结束与化疗一年后比较,差异有统计学意义。血清雌二醇水平比较,三个时间段差异均有统计学意义。结论乳腺癌化疗致闭经者卵巢功能衰竭,在卵巢体积上表现稍晚,窦卵泡计数与卵巢间质动脉PSV及RI表现更敏感。 Objective To evaluate the structure and hemodynamics of ovarian tissue in patients with amenorrhoea by transvaginal sonography and to provide important reference information for clinical treatment. Methods 48 cases of postoperative patients with amenorrhoea after chemotherapy were treated with transvaginal sonography, including ovary size, antral follicle count, ovarian interstitial blood flow force, before chemotherapy and chemotherapy after 6 courses of chemotherapy and one year after chemotherapy. learn. Serum estradiol levels were also measured at the same time. Results Ovarian volume comparison: before chemotherapy and chemotherapy after a year, the difference was statistically significant, the end of chemotherapy and chemotherapy after a year, the difference was statistically significant; antral follicle count comparison: the three time periods were statistically significant ; Comparison of the peakinssystolic velocity (PSV) and the resistance index (RI) between the ovarian interstitial artery: one year after chemotherapy and before chemotherapy, the difference was statistically significant. After the end of chemotherapy and one year after chemotherapy, The difference was statistically significant. Serum estradiol levels, three time differences were statistically significant. Conclusions Chemotherapy of breast cancer amenorrhea ovarian failure, performance in the ovarian volume later, antral follicle count and ovarian interstitial artery PSV and RI performance more sensitive.