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目的检测结直肠癌患者外周血中基质细胞源性因子-1(SDF-1)的表达水平及其临床意义。方法应用ELISA法检测53例结直肠癌患者术前外周血中SDF-1表达水平,分析其与结直肠癌临床病理的关系。结果血清SDF-1水平:结直肠癌患者(n=53)[(6803.5±1454.2)pg/ml;3275.1~9621.6 pg/ml]明显高于正常对照组(n=20)[(5447.6±1028.6)pg/ml;4156.7~6922.3 pg/ml](P<0.01),发生远处转移结直肠癌患者(n=24)[(7545.2±1138.7)pg/ml;3575.2~9621.6 pg/ml]明显高于未发生转移的患者(n=29)[(6125.3±1391.4)pg/ml;3275.1~8734.5 pg/ml](P<0.01)。结论 SDF-1可能是预测或检测结直肠癌远处转移的重要标志物。
Objective To detect the expression of stromal cell derived factor-1 (SDF-1) in peripheral blood of patients with colorectal cancer and its clinical significance. Methods The expression of SDF-1 in peripheral blood of 53 patients with colorectal cancer was detected by ELISA. The relationship between the expression of SDF-1 and clinicopathological features of colorectal cancer was analyzed. Results Serum SDF-1 levels were significantly higher in patients with colorectal cancer (n = 53) [(6803.5 ± 1454.2) pg / ml and 3275.1 ~ 9621.6 pg / ml] (n = 24) [(7545.2 ± 1138.7) pg / ml; 3575.2 ~ 9621.6 pg / ml] were significantly higher in patients with distant metastasis than in those with distant metastasis (pg / ml; 4156.7-6922.3 pg / Patients without metastasis (n = 29) [(6125.3 ± 1391.4) pg / ml; 3275.1 ~ 8734.5 pg / ml] (P <0.01). Conclusion SDF-1 may be an important marker for predicting or detecting the distant metastasis of colorectal cancer.