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目的:研究 5 Fu高分子微球对实验性质滤过术后瘢痕形成的疗效及毒性。方法 :对 40只兔行巩膜后唇咬切术 ,实验组术中结膜下注射 1ml 5 Fu微球 ,对照组术中结膜下注射 2 5 % 5 Fu注射液 10mg。结果 :术后实验组和对照组眼内压和滤过泡的存留有显著性差异。 5 Fu微球药物浓度变化范围 2 6 47～ 9 872ug/ml,持续 14天 ,可降低它的毒性 ,组织学显示两组纤维增生有显著差异。结论 :PTL EO PLA聚合微球通过释放 5 Fu ,防止瘢痕增殖引起的滤过不畅 ,降低 5 Fu的毒性 ,提高兔眼滤过术的成功率 ,有临床应用价值
Objective: To study the curative effect and toxicity of 5 Fu polymeric microspheres on experimental scar formation after filtration. Methods: Forty rabbits underwent sciatic posterior lip bite resection. In the experimental group, 1 ml of 5 Fu microspheres were injected subconjunctivally. In the control group, 10 mg of 25% 5 Fu injection was injected subconjunctivally. Results: Postoperative experimental group and control group intraocular pressure and filtered bleb retention were significantly different. 5 Fu microspheres drug concentration range 2647 ~ 9 872ug / ml for 14 days, can reduce its toxicity, histology showed a significant difference between the two groups of fibrous proliferation. CONCLUSION: PTL EO PLA polymeric microspheres have a clinical value by releasing 5 Fu, preventing poor filtration caused by scar proliferation, reducing the toxicity of 5 Fu and improving the success rate of rabbit ocular filtration