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We evaluated the antitumor effect of combined therapy with tegafur/uracil(UFT) plus leucovorin(LV) (UFT/LV) and protein-bound polysaccharide,PSK,in three mouse models of transplantable tumors. UFT/LV showed antitumor effect against Meth A sarcoma,and the antitumor effect was enhanced when PSK given concomitantly. UFT/LV showed antitumor effect to Lewis lung carcinoma and PSK alone also showed antitumor effect at high dose,but a combination of UFT/LV and PSK resulted in no enhanced antitumor effect. Colon 26 carcinoma was weakly responsive to UFT/LV,and no enhancement of antitumor effect was found even PSK was used in combination. In conclusion,while the effect of PSK varies depending on tumor,combined use of UFT/LV and PSK may be expected to augment the antitumor effect.
UFT / LV showed antitumor effect of combined therapy with tegafur / uracil (UFT) plus leucovorin (LV) (UFT / LV) and protein-bound polysaccharide, PSK, in three mouse models of transplantable tumors. sarcoma, and the antitumor effect was enhanced when PSK given concomitantly. UFT / LV showed antitumor effect to Lewis lung carcinoma and PSK alone also showed antitumor effect at high dose, but a combination of UFT / LV and PSK resulted in no enhanced antitumor effect. Colon 26 carcinoma was weakly responsive to UFT / LV, and no enhancement of antitumor effect was found even PSK was used in combination. In conclusion, while the effect of PSK varies depending on tumor, combined use of UFT / LV and PSK may be expected to augment the antitumor effect.