抗原处理相关转运蛋白 (TAP)负责内源性抗原从胞浆到内质网的转运 ,在MHCⅠ类分子的抗原呈递过程中发挥重要的作用。TAP属于ABC超家族成员 ,其两个亚基共同参与组成肽结合部位 ,由于具有一定的多态性 ,对底物具有选择性转运现象。TAP同时还参与了MHCⅠ类分子的组装。体内外多种因素可以调节TAP的表达和活性 ,从而影响病毒感染过程和肿瘤的发生 Antigen Handling Related Transport Proteins (TAPs) are responsible for the transport of endogenous antigens from the cytoplasm to the endoplasmic reticulum and play an important role in the antigen presentation of MHC class I molecules. TAP is a member of the ABC superfamily, and its two subunits are involved in the peptide binding site. Due to its polymorphism, TAP selectively transports substrates. TAP is also involved in the assembly of MHC class I molecules. A variety of factors in vitro and in vivo can regulate TAP expression and activity, thus affecting the viral infection process and tumor occurrence