论文部分内容阅读
目的探讨在全身给药时缺氧性肺血管收缩（ＨＰＶ）对肺组织药物浓度的影响及其对策，为临床上常发生ＨＰＶ的疾病寻求新的治疗方法。方法使兔右肺吸低氧气体，用胸窗法观察ＨＰＶ及吸入尼卡地平对ＨＰＶ的作用；右肺ＨＰＶ时静脉注射先锋霉素Ｖ，观察两肺组织药物浓度及吸入尼卡地平的影响。结果肺平均微动脉直径缺氧前后比较ｄ＝５.４４，ｔ＝９.５４３，Ｐ<０.００１，吸入尼卡地平前后比较ｄ＝５．１１，ｔ＝７．５１５，Ｐ<０．００１；右肺ＨＰＶ时组织药物浓度低于左肺，ｄ＝３２７．８，ｔ＝５．６７６，Ｐ＜０．００１；吸入尼卡地平后两肺组织药物浓度比较ｄ＝４１．３３，ｔ＝１．６０７，Ｐ>０．０５。结论ＨＰＶ降低肺组织药物浓度，吸入尼卡地平能抑制ＨＰＶ，提高该部位药物浓度。
Objective To investigate the effect of systemic hypoxia pulmonary vasoconstriction (HPV) on drug concentration in lung tissue and its countermeasures in order to find a new treatment method for the common HPV-related diseases. Methods The right lungs of the rabbits were exposed to hypoxia, the effects of HPV and nicardipine on HPV were observed by the chest wall method, and the cephalosporin V was injected intravenously into the right lungs of the rabbits to observe the effects of nicotine and inhaled nicotine . Results Before and after hypoxia, the mean diameter of pulmonary arteries was d = 5.44, t = 9.543, P <0.001. Before and after nicardipine inhalation, d = 5.11, t = 7.515, P <0. 001; the right lung HPV tissue drug concentrations lower than the left lung, d = 327.8, t = 5.676, P <0.001; inhalation of nicardipine drug concentration in the two lungs after comparison d = 41.33, t = 1.607, P> 0.05. Conclusions HPV can reduce the drug concentration in lung tissue and inhale nicardipine can inhibit HPV and increase the drug concentration in this area.