Rb基因是一种抑癌基因,Rb基因所表达的产物称为Rb蛋白,目前已在多种恶性肿瘤中发现有Rb基因的缺失、突变以及Rb蛋白的表达降低。白血病是起源于造血系统的一类恶性疾病,其病因尚不完全清楚。本文拟就Rb蛋白在急性非淋巴细胞白血病中的表达及其意义进行探讨。1 材料和方法1.1 病例 1997至1999年急性淋巴细胞白血病20例,均经过骨髓穿刺细胞学检查确诊,其中男11例,女9例,年龄32至58岁,平均45岁;非白血病病例20例,男10例,女10例,年龄26～56 Rb gene is a tumor suppressor gene, Rb gene expressed product called Rb protein, has been found in a variety of malignant tumors Rb gene deletion, mutation and Rb protein expression decreased. Leukemia is a type of malignant disease that originated in the hematopoietic system, the etiology of which is not fully understood. This article intends to Rb protein expression in acute non-lymphocytic leukemia and its significance. 1 Materials and Methods 1.1 cases of acute lymphoblastic leukemia from 1997 to 1999, 20 cases were diagnosed by bone marrow biopsy, including 11 males and 9 females, aged 32 to 58 years, mean 45 years; 20 cases of non-leukemia cases , 10 males and 10 females, aged 26 ~ 56