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本文对100例正常及病变子宫内膜标本(正常5例,轻度增生过长16例,腺囊型增生24例,腺瘤样增生17例,不典型增生17例,内膜癌19例,内膜间质肉瘤2例)进行 DNA 含量及 S 期细胞数测定。发现DNA 含量及 S 期细胞数百分比依次递增,DNA 非整倍体率分别为0、12.5%、33.3%、50.0%、50.0%、73.7%及50.0%。随访77例,对其中48例未手术者进行 DNA 倍体和阴道异常出血关系分析,认为孕激素治疗是有益的,可使恶性危险倾向有所改善。提示在孕激素正规治疗下对 DNA 非整倍体患者可长期随访、观察,不急于手术治疗。
In this paper, 100 cases of normal and diseased endometrial specimens (normal 5 cases, 16 cases of mild hyperproliferation, adenoid cystic hyperplasia in 24 cases, adenoma-like hyperplasia in 17 cases, 17 cases of atypical hyperplasia, endometrial carcinoma in 19 cases, 2 cases of endometrial stromal sarcoma) DNA content and S phase cell number determination. The results showed that the DNA content and the percentage of S phase cells increased in sequence and the rates of DNA aneuploidy were 0,12.5%, 33.3%, 50.0%, 50.0%, 73.7% and 50.0%, respectively. Follow-up of 77 cases, 48 cases of non-operative analysis of DNA ploidy and vaginal bleeding, that progesterone treatment is beneficial, can make the risk of malignant tendency to be improved. Tip progesterone formal treatment of DNA aneuploidy patients with long-term follow-up, observation, not in a hurry surgery.