近年来对皮肤T细胞淋巴瘤的研究发现:皮肤T细胞淋巴瘤细胞的某些表型可能在疾病发展过程中丢失,或表达一些奇特的新表型;Southern印迹分析检测出T细胞受体基因重排带,提示该病是一种克隆性恶性疾病。应用多种单克隆抗体检测皮肤T细胞淋巴瘤细胞表型的变化及Southern印迹技术检测克隆性重排带可能对该病的早期诊断,鉴别诊断和预后判定具有意义。 In recent years, studies on cutaneous T-cell lymphoma have found that certain phenotypes of cutaneous T-cell lymphoma cells may be lost during disease development or express some novel new phenotypes; Southern blot analysis detects T-cell receptor gene Rearranged band, suggesting that the disease is a clonal malignant disease. The detection of the phenotype of cutaneous T-cell lymphoma using multiple monoclonal antibodies and the detection of clonal rearrangements by Southern blotting may be of great value in the early diagnosis, differential diagnosis and prognosis of the disease.