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目的观察及评价托吡酯对老年性继发性癫癎患者的临床疗效和安全性。方法收集2007年1月~2008年12月神经内科门诊患者中60岁以上老年继发性癫癎患者40例,只给予托吡酯治疗,而且未服用其它任何抗癫癎药物,于3、6、12个月进行随访,评价托吡酯的临床疗效和安全性。结果 40例患者的有效率均在80%以上。无1例患者发生重度不良反应。结论托吡酯治疗老年继发性癫癎患者有效且安全。
Objective To observe and evaluate the clinical efficacy and safety of topiramate in senile patients with secondary epilepsy. Methods Forty patients with senile secondary epilepsy who were over 60 years of age from January 2007 to December 2008 in outpatient department of neurology were enrolled in topiramate treatment only and did not take any other antiepileptic drugs at 3,6,12 Month follow-up, evaluation of topiramate clinical efficacy and safety. The results of 40 patients were more than 80% efficient. None of the patients had severe adverse reactions. Conclusion Topiramate is effective and safe in elderly patients with secondary epilepsy.