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为了探讨急进高海拔地区机体对低压、低氧环境的适应机制,将海拔10m 处的平原大鼠快速带至海拔2261m 再带入海拔3800m 处,用放射免疫法测定大鼠血浆心钠素、肾素、血管紧张素Ⅱ和醛固酮的浓度。结果发现:(1)随海拔递增,大鼠血心钠素浓度逐渐升高,肾素及血管紧张素Ⅱ的含量也呈上升趋势,醛固酮浓度逐渐下降,统计学处理有显著性差别;(2)急进高海拔,心钠素降低了醛固酮对肾素、血管紧张素Ⅱ的反应性,使醛固酮处于低水平状态。
In order to explore the mechanism of adaptation to low pressure and hypoxic environment in high altitude areas, plain rats at altitude of 10 m were quickly brought to an altitude of 2261 m and brought to an altitude of 3800 m. Radioimmunoassay was used to determine plasma atrial natriuretic peptide Hormone, angiotensin II and aldosterone concentrations. The results showed that: (1) With the increasing of altitude, the concentration of blood atrial natriuretic peptide increased gradually, and the content of renin and angiotensin Ⅱ also increased. The concentration of aldosterone decreased gradually. There was a significant difference between the two groups ) Acute high altitude, atrial natriuretic aldosterone reduces the reactivity of renin, angiotensin Ⅱ, aldosterone in a low level state.