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用国产洛哌丁胺治疗各种病因引起的非感染性急慢性腹泻共81例,以复方地芬诺酯治疗非感染性急慢性腹泻62例作对照。急性腹泻病例先口服洛哌丁胺4mg,以后每次2mg,每天总量不得超过16mg。慢性腹泻病例,每日给服洛哌丁胺2-6mg。连续给药10d无效者停药。儿童剂量根据年龄或体重调整。结果:在急性病例中洛哌丁胺与复方地芬诺酯控制腹泻的效果相似;在慢性腹泻病例中,前者的疗效明显优于后者。洛哌丁胺治疗后血、尿常规,肝、肾功能与心电图观察均无异常。
A total of 81 cases of non-infectious acute and chronic diarrhea were treated with domestic loperamide in a variety of etiologies, 62 cases of non-infectious acute and chronic diarrhea were treated with compound diphenoxylate. Acute diarrhea cases first oral loperamide 4mg, after each 2mg, the total amount per day shall not exceed 16mg. Chronic diarrhea cases, daily dose of loperamide 2-6mg. Continuous administration of 10d invalid drug withdrawal. Child dose adjusted according to age or weight. Results: In acute cases loperamide and diphenoxylate controlled diarrhea similar effect; in the case of chronic diarrhea, the former was significantly better than the latter. Loperamide treatment of blood, urine, liver, kidney function and ECG were normal.