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目的:探讨COX-2和MMP-9在胃癌组织中的表达及其与幽门螺杆菌感染和胃部转移侵袭的关系。方法:采用快速尿素酶试验及Warthin-Starry银染色法检测45例胃癌标本中幽门螺杆菌感染情况,采用免疫组织化学法检测COX-2和MMP-9在胃癌组织中的表达,对其与幽门螺杆菌感染和胃癌患者临床病理特征的相关性进行分析。结果:①幽门螺杆菌感染组胃癌中浆膜侵袭和淋巴结转移率均高于无幽门螺杆菌感染组(P<0.05)。②胃癌浆膜侵袭组和淋巴结转移组中COX-2、MMP-9蛋白表达阳性率均分别显著高于无胃癌浆膜侵袭组、淋巴结转移组(P<0.05)。③幽门螺杆菌感染与COX-2和MMP-9表达具有相关性。结论:幽门螺杆菌感染能够增加胃癌的侵袭转移能力,其机制可能与COX-2和MMP-9表达增加有关。
Objective: To investigate the expression of COX-2 and MMP-9 in gastric carcinoma and their relationship with Helicobacter pylori infection and gastric metastasis. Methods: The infection of Helicobacter pylori in 45 gastric cancer specimens was detected by rapid urease test and Warthin-Starry silver staining. The expressions of COX-2 and MMP-9 in gastric cancer tissues were detected by immunohistochemistry. Helicobacter infection and gastric cancer patients with clinical and pathological features were analyzed. Results: Serum invasion and lymph node metastasis in H. pylori infection group were higher than those in H. pylori infection group (P <0.05). ② The positive rates of COX-2 and MMP-9 in serosa invasion group and lymph node metastasis group were significantly higher than those without gastric serosa invasion group and lymph node metastasis group (P <0.05). Helicobacter pylori infection was correlated with the expression of COX-2 and MMP-9. Conclusion: Helicobacter pylori infection can increase the invasion and metastasis of gastric cancer, the mechanism may be related to the increased expression of COX-2 and MMP-9.