论文部分内容阅读
链球菌制剂OK-432是抗肿瘤的免疫佐剂,Ishii和Hojo等曾先后报道OK-432激活的大鼠巨噬细胞介导的细胞毒性在体内、外均能抑制肿瘤生长.本文介绍了OK-432在接种MM2乳癌细胞的小鼠中所诱生的腹腔渗出细胞的抗体依赖性细胞介导的细胞毒作用.作者用7～9周龄雌性C3H/He小鼠腹腔注射OK-432 4天以后获得腹腔渗出细胞,然后加入经OK-432处理存活60天以上、并能耐受MM2乳癌细胞再攻击的无肿瘤C3H/He小鼠的抗血清,最后再加2×10~5细胞/ml的~(51)Cr标记的MM2乳癌细胞,共同培养于37℃
OK-432 streptococcal preparation is an anti-tumor immune adjuvant, Ishii and Hojo have reported that OK-432 activated rat macrophage-mediated cytotoxicity both in vivo and in vitro can inhibit tumor growth.This article describes the OK -432 Antibody-dependent cell-mediated cytotoxicity of peritoneal exudate cells induced in mice inoculated with MM2 breast cancer cells The authors used intraperitoneal injection of OK-432 4 in female C3H / He mice of 7-9 weeks of age Day after the peritoneal exudate cells, and then added OK-432 survived for more than 60 days, and can tolerate MM2 breast cancer cells to attack the tumor-free C3H / He mouse antiserum, and finally add 2 × 10 ~ 5 cells / ml of ~ (51) Cr-labeled MM2 breast cancer cells co-cultured at 37 ° C