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目的探索五种尿微量蛋白检测在肾脏病及糖尿病中的临床意义。方法用放免法测定50例正常人及83例原发性肾疾病、113例2型糖尿病患者尿α1微球蛋白(α1MG)、β2微球蛋白(β2MG)、TH糖蛋白(THP)、白蛋白(Alb)及IgG排泄水平。结果随内生肌酐清除率下降,尿THP排泄水平下降;尿α1MG、(β2MG)、Alb及IgG排泄水平增加,但当肾功能不全时,上述蛋白排泄水平增加不明显(P>005);糖尿病早期,尿α1MG排泄水平已明显增加(P<001)。五种尿蛋白与CCr均相关(P<005～001)。结论五种尿蛋白均系诊断早期肾损害指标,以α1MG最敏感。但不适用于肾功能不全时的判断。
Objective To explore the clinical significance of detecting urinary microalbumin in kidney disease and diabetes mellitus. Methods The urinary α1 microglobulin (α1MG), β2 microglobulin (β2MG), THP, albumin (α1MG) in 50 normal subjects and 83 primary renal diseases and 113 patients with type 2 diabetes mellitus were measured by radioimmunoassay. (Alb) and IgG excretion levels. The results showed that the urinary THP excretion decreased with the decrease of endogenous creatinine excretion; the urinary excretion of α1MG, (β2MG), Alb and IgG increased, but the level of excretion of protein was not significantly increased when renal insufficiency was present (P> 0.05) Early urinary α1MG excretion levels have been significantly increased (P <001). Five urinary proteins were correlated with CCr (P <005 ~ 001). Conclusions All five urinary proteins are diagnostic indicators of early renal damage, with α1MG being the most sensitive. But does not apply to the judgment of renal insufficiency.