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作者曾报道吴茱萸碱对支气管的收缩作用可能与 vanilloid 受体的活性有关,其辣椒素样作用与辣椒素作用的强度相当。还有报道称吴茱萸碱对离体豚鼠左心房具有正性肌力和正性变时作用,但机理不清楚,且吴茱萸次碱的强心作用未见报道。因此作者研究了吴茱萸碱和吴茱萸次碱的强心作用及其与vanilloid 受体的关系。离体豚鼠右心房在60 min 平衡期后被彻底清洗,再平衡15 min。然后将超大剂量的吴茱萸碱、吴茱萸次碱及对照药辣椒素(分
The authors have reported that the bronchoconstriction effect of evodiamine may be related to the activity of the vanilloid receptor, and its capsaicinoid effect is comparable to that of capsaicin. It has also been reported that evodiamine has a positive inotropic and positive effect on isolated left guinea pig guinea pigs, but the mechanism is unclear, and the cardiotonic effect of rutacarpine has not been reported. Therefore, the authors studied the cardiotonic effects of evodiamine and rutacarpine and their relationship with vanilloid receptors. The isolated right guinea pig guinea pigs were thoroughly washed after a 60-min equilibrium period and re-equilibrated for 15 min. Then the ultra-large dose of evodiamine, rutacarpine and control drug capsaicin (points