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木藜芦毒素(Grayanotoxin,GTX)是从一些木藜芦属植物的叶中提取分离的一类有毒成分,它们具有一个独特的四环二萜碳骨架。GTX的毒性是由于它们能够刺激某些可兴奋组织细胞膜上的Na~-通道的开放。本研究试图分离得到异木藜芦毒素Ⅱ(iso-GTXⅡ)并证实其化学结构。
Gratinotoxin (GTX) is a toxic component extracted from the leaves of some plants of the genus Hibiscus. It has a unique tetracyclic diterpene carbon skeleton. The toxicity of GTX is due to their ability to stimulate the opening of Na~-channels on the membranes of certain excitable tissues. This study sought to isolate iso-GTXII and confirm its chemical structure.