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目的探讨胎盘生长因子(placental growth factor,PIGF)在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者中的水平变化及临床意义。方法选取2011年1月—2012年3月治疗的COPD患者60例,其中稳定期患者30例为稳定组,急性加重期患者30例为急性组,选取肺功能检测正常的同期健康查体者30例为对照组。所有受试者先行肺功能通气检查,肺功能测定有专业人员行标准化操作。ELISA测定血清中PIGF水平。计量资料用x±s表示,各组间均数比较采用单因素方差分析,相关性分析采用Pearson相关分析。取t=0.05为检验水准,P<0.05为差异有统计学意义。结果稳定组、急性组血清PIGF水平[(28.38±9.49)、(36.88±12.47)pg/ml]均显著高于对照组,1 s用力呼气容积占预计值百分比(forced expiratory volume in one second to predicted value ratio,FEV1%)(59.52±17.65、53.02±18.39)低于对照组,比较差异均有统计学意义(均P<0.05);急性组血清PIGF水平高于稳定组,比较差异有统计学意义(P<0.05)。急性组血清PIGF水平与FEV1%预计值呈负相关(r=-0.506,P<0.05);稳定组血清PIGF水平与FEV1%预计值呈负相关(r=-0.601,P<0.05)。结论 COPD急性加重期、稳定期患者血清PIGF水平均升高,且与COPD的严重程度呈正相关,PIGF可能在COPD发病机制中起一定作用。
Objective To investigate the changes and clinical significance of placental growth factor (PIGF) in patients with chronic obstructive pulmonary disease (COPD). Methods Sixty COPD patients were selected from January 2011 to March 2012. Among them, 30 patients in stable group were in stable group, 30 patients in acute exacerbation group were acute group, 30 healthy subjects with normal pulmonary function test in the same period Example for the control group. All subjects underwent pulmonary function ventilation examination, pulmonary function tests with professional staff to standardize the operation. ELISA assay of serum PIGF levels. Measurement data with x ± s, said the mean comparison between groups using one-way ANOVA, correlation analysis using Pearson correlation analysis. Take t = 0.05 as the test level, P <0.05 for the difference was statistically significant. Results The serum levels of PIGF in the stable and acute groups were significantly higher than those in the control group [(28.38 ± 9.49) and (36.88 ± 12.47) pg / ml], respectively. The forced expiratory volume in one second to (P <0.05). The level of PIGF in acute group was higher than that in stable group (P <0.05), the difference was statistically significant Significance (P <0.05). The level of PIGF in acute group was negatively correlated with the predicted FEV1% (r = -0.506, P <0.05). The level of PIGF in stable group was negatively correlated with the predicted value of FEV1 (r = -0.601, P <0.05). Conclusions The levels of serum PIGF in patients with acute exacerbation of COPD and in stable patients are elevated, and are positively correlated with the severity of COPD. PIGF may play a role in the pathogenesis of COPD.