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目的:检测冠心病中医不同证型血浆纤维蛋白原(FIB)、血清超敏C反应蛋白(HS-CRP)水平,为冠心病的中医辨证分型提供客观依据,为冠心病的辨证论治提供参考。方法:将179例冠心病患者,中医辨证分为心血瘀阻、痰浊内阻、阴寒凝滞、心肾阴虚、气阴两虚、阳气虚衰型6组,选对照组30例,测定FIB、HS-CRP水平。结果:①各组中FIB测值高于正常的比例阳以气虚衰型最高,具体测值为阳气虚衰型>阴寒凝滞型>痰浊内阻型>气阴两虚型>心血瘀阻型>心肾阴虚型>对照组;冠心病中医证型中HS-CRP测值为心血瘀阻型>阳气虚衰型>痰浊内阻型>阴寒凝滞型>对照组>气阴两虚型>心肾阴虚型。②7组的FIB及HS-CRP水平的两两比较的21对中,均为6对有统计学差异,15对无统计学差异;③急性冠脉综合征(ACS)的阳性率在冠心病的6证型组中有统计学差异。结论FIB、HS-CRP对冠心病中医辨证分型有一定参考价值,尤其是FIB在阳气虚衰型,HS-CRP在心血瘀阻型中的作用更大。
Objective: To detect the levels of plasma fibrinogen (FIB) and serum high-sensitivity C-reactive protein (HS-CRP) in different TCM syndromes of coronary heart disease and provide objective evidences for TCM syndrome differentiation of coronary heart disease and provide references for syndrome differentiation and treatment of coronary heart disease. Methods: 179 patients with coronary heart disease and TCM syndrome differentiation were divided into 6 groups: blood stasis, phlegm internal resistance, yin and blood stagnation, heart and kidney yin deficiency, qi and yin deficiency, yang deficiency and failure type, 30 cases in control group FIB, HS-CRP levels. Results: ① The FIB values in each group were higher than the normal ones. The yang deficiency syndrome type was the highest, and the specific values were yang deficiency syndrome> yin deficiency syndrome> phlegm obstruction syndrome> qi and yin deficiency syndrome> blood stasis syndrome Type> heart-kidney-yin-deficiency> control group; HS-CRP in TCM syndrome type of coronary heart disease was blood stasis type> Yang-qi-deficiency type> phlegm-turbidity type> Virtual> Heart and Kidney type. ② The 21 pairs of 21 pairs of FIB and HS-CRP levels in 7 groups were statistically significant, and there was no significant difference in 15 pairs; ③ The positive rate of acute coronary syndrome (ACS) in coronary heart disease There were significant differences in 6 syndrome groups. Conclusion FIB and HS-CRP have some reference value for syndrome differentiation of coronary heart disease, especially FIB in Yang Deficiency and HS-CRP in blood stasis type.