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早在七十年代即有学者应用合成 GnRH在闭经妇女中诱发排卵,通常给 GnRH 皮下注射,一天三次,剂量在100～500μg 之间。尽管在理论上 GnRH 比人促性腺激素疗法有显著优越性,但临床实践表明这种给药法的总排卵率极少超过安慰剂水平。近年来,由于对下丘脑 GnRH 脉冲式释放的生理意义的深入了解,许多学者通过一种小型自动输液泵长期以脉冲形式给予小剂量 GnRH,在各种类型的下丘脑闭经患者中诱发排卵和妊娠,使 GnRH 作为促排卵剂的前景大为改观。本文仅就这方面的基础和临床研究进展作一综述。
As early as the seventies scholars have used synthetic GnRH induced ovulation in amenorrhea women, usually give GnRH subcutaneous injection three times a day, the dose between 100 ~ 500μg. Although in theory GnRH is significantly superior to human gonadotropin therapy, clinical practice has shown that the overall ovulation rate of this route of administration rarely exceeds that of placebo. In recent years, due to the deep understanding of the physiological significance of hypothalamic GnRH pulsatile release, many scholars have long-term pulsed administration of small doses of GnRH through a small automatic infusion pump to induce ovulation and pregnancy in various types of hypothalamic amenorrhea patients , So that GnRH prospects for ovarian promotion greatly improved. This article reviews only the basic and clinical research progress in this area.