论文部分内容阅读
AIM:To explore the effects of recombinant human growthhormone (rhGH) on the remnant liver after hepatectomy inhepatocellular carcinoma with liver cirrhosis.METHODS:Twenty-four patients with hepatocellular carcinomawho underwent hepatectomy were randomly divided into 2groups:parenteral nutrition (PN) group (n=12) and rhGH+PNgroup (n=12).Liver function,blood glucose,AFP,serumprealbumin and transferrin were detected before operation,at post-operative d 1 and d 6.Albumin (ALB) mRNA in liverbiopsy specimens was detected by RT-PCR at post-operatived 6.Liver Ki67 immunohistochemical staining was studied.RESULTS:On post-operative d 6,compared with PN group,the levels of blood glucose,serum prealbumin,transferrin,the expression of hepatic ALB mRNA and liver Ki67 labelingindex were higher in rhGH+PN group.CONCLUSION:rhGH can improve protein synthesis andliver regeneration after hepatectomy in hepatocellularcarcinoma with liver cirrhosis.
AIM: To explore the effects of recombinant human growthhormone (rhGH) on the remnant liver after hepatectomy in hepatocellular carcinoma with liver cirrhosis. METHODS: Twenty-four patients with hepatocellular carcinoma who underwent hepatectomy were randomly divided into 2 groups: parenteral nutrition (PN) group = 12) and rhGH + PNgroup (n = 12) .Liver function, blood glucose, AFP, serumprealbumin and transferrin were detected before operation, at post-operative d 1 and d 6.Albumin (ALB) mRNA in liverbiopsy specimens was detected by RT-PCR at post-operatived 6. Liver Ki67 immunohistochemical staining was studied .RESULTS: On post-operative d 6, compared with PN group, the levels of blood glucose, serum prealbumin, transferrin, the expression of hepatic ALB mRNA and liver Ki67 labelingindex were higher in rhGH + PN group.CONCLUSION: rhGH can improve protein synthesis andliver regeneration after hepatectomy in hepatocellularcarcinoma with liver cirrhosis.