肝素酶(heparanase,Hpa)是一种糖苷内切酶,可特异性地降解硫酸肝素,破坏细胞外基质和血管基底膜的完整性,释放结合于硫酸肝素上的生长因子、酶类分子等生物活性分子,促进细胞增生和微血管的生长,使肿瘤易于生长转移。国内外的大量研究已证明了肿瘤组织中肝素酶异常高表达,而抑制肝素酶的活性或表达可明显抑制肿瘤的生长、转移和血管发生。 Heparanase (Hpa) is an endoglycosidase that specifically degrades heparin sulfate, disrupts the integrity of the extracellular matrix and vascular basement membrane, releases growth factors, enzymes, and the like that bind to heparin sulfate Bioactive molecules, promote cell proliferation and microvascular growth, so that tumor growth and metastasis. Numerous studies both at home and abroad have demonstrated abnormally high expression of heparanase in tumor tissues, while inhibition of heparinase activity or expression can significantly inhibit tumor growth, metastasis and angiogenesis.