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目的:探讨米非司酮加桂枝茯苓胶囊在治疗子宫肌瘤中的应用。方法:30例子宫肌瘤患者口服米非司酮10mg每天,连服6个月后改服桂枝茯苓胶囊3片每次,每日三次,连服6个月。比较治疗前后症状,患者子宫和肌瘤体积、血生殖激素水平、子宫血流阻力变化、血液流变学变化。结果:子宫及肌瘤体积较前缩小(P<0.05);血生殖激素水平明显下降;子宫动脉及肌瘤血管阻力指数增加(P<0.05)。血液流变学方法表明:全血还原比粘度和全血比粘度降低,红细胞比容下降,血浆比粘度下降(P<0.05)。结论:米非司酮加桂枝茯苓胶囊通过降低生殖激素水平,减少子宫血流,改变血液流变学而发挥其作用。
Objective: To investigate the application of mifepristone and Guizhi Fuling capsules in the treatment of uterine fibroids. Methods: 30 cases of uterine fibroids oral mifepristone 10mg daily, even for 6 months after serving clothes Guizhi Fuling capsules 3 tablets three times a day, and even for 6 months. The symptoms before and after treatment, uterine and fibroid volume, blood reproductive hormone levels, changes in uterine blood flow resistance, and changes in hemorheology were compared. Results: The volume of uterus and fibroids decreased compared with the previous group (P <0.05). The level of blood reproductive hormone decreased significantly. The vascular resistance index of uterine artery and fibroids increased (P <0.05). Hemorheology methods showed that the whole blood reduced viscosity and whole blood viscosity decreased, hematocrit decreased, plasma viscosity decreased (P <0.05). Conclusion: Mifepristone and Guizhi Fuling Capsule play their roles by reducing the level of reproductive hormones, reducing uterine blood flow and changing the blood rheology.