在雌猴妊娠第12天采用灌胃法一次性给予TCDD，剂量为1.0、2.0、4.0μg/kg.bw，每个剂量组4个动物。对照组(7个动物)给予相同体积的溶媒(丙酮-色拉油)。结果发现母猴在染毒10天后相继出现食欲下降、体重降低、脱毛、皮炎和贫血等中毒症状，染毒组12只猴子有10只在怀孕的第22到32天发生早期胚胎丢失。结果表明，低剂量TCDD可导致妊娠期猕猴出现中毒症状，并影响妊娠结局。“,”Females macaques were administrated single doses of 1, 2,4pg/kg TCDD(n = 4 per dose group)on gestational day (GD)12.The controls(n = 7)received the same dosing volume of acetone-coin oil. The results showed that poor appetite, weight loss, alope-cia, dermatitis, anemia and other toxic reactions were recordedsince rtrteatment day 10, and early fetal loss occurred between GDs22 and 32 in 10 of the 12 animals treated, with TCDD. The resultsdemonstrated that toxicity was induced by low level TCDD inpregnant macaques and pregnancy outcomes were affected too.