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目的肿瘤具有遗传性,提高家族性肿瘤遗传认识的重要性,有利于对具有肿瘤家族史患者的早发现与早治疗。本文报告1例乳腺癌导管原位癌病例,同时介绍该病例肿瘤多发家系。方法分析南昌市第三医院2015-09-15收治的1例无肿块触及的乳腺癌患者临床资料及肿瘤家族病史。结果患者经乳腺摄影检查片示右乳外上方呈簇状泥沙样钙化集聚,术后病理提示乳腺导管原位癌(高级别)。该家系4代28人,11例(39.3%)癌症患者,其中肺癌2例,结直肠癌2例,胃癌1例,肝癌1例,膀胱癌1例,子宫内膜癌1例,乳腺癌1例,脑膜胶质瘤1例,肾母细胞瘤1例。结论该家系肿瘤具有家族聚集现象,呈常染色体显性遗传。
The purpose of the tumor hereditary, improve the genetic understanding of the importance of familial tumors, is conducive to patients with a family history of cancer early detection and early treatment. This article reports a case of ductal carcinoma in situ in breast cancer, and at the same time introduced the case of multiple tumor families. Methods The clinical data and tumor family history of a breast cancer patient without lumps contacted by the Third Hospital of Nanchang in 2015-09-15 were analyzed. Results The patient showed cluster-like sediment-like calcification at the top of the right breast after the mammography examination. Postoperative pathology showed ductal carcinoma in situ (high grade). The family of 4 generations of 28 people, 11 cases (39.3%) of cancer patients, including lung cancer in 2 cases, colorectal cancer in 2 cases, 1 case of gastric cancer, 1 case of liver cancer, 1 case of bladder cancer, 1 case of endometrial cancer, 1 case of breast cancer 1 case of meningioma, 1 case of nephroblastoma. Conclusion The pedigree tumor has familial aggregation and is autosomal dominant.