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目的:观察麝香保心丸抑制模型大鼠急性心肌梗死(AMI)后血流动力学参数及梗死组织炎性因子含量的作用,探讨其改善AMI后心室重构的机制。方法:结扎模型大鼠冠脉左前降支造成AMI模型,70只SD雄性大鼠随机分为空白组、假手术组、模型组、麝香保心丸低剂量组(14 mg.kg-1.d-1)、麝香保心丸高剂量组(28 mg.kg-1.d-1)及辛伐他汀组(2 mg.kg-1.d-1)。均连续ig 2周后,测定各组大鼠的血流动力学指标,检测梗死组织中肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)的含量。结果:与空白组比较,模型组大鼠左室收缩末压(LVESP)、左室内压最大上升速率(LV+dp/dtmax)和左室内压最大下降速率(LV-dp/dtmax)显著降低(P<0.01),左室舒张末压(LVEDP)显著增加(P<0.01),TNF-α,IL-6含量显著升高(P<0.01);与模型组比较,麝香保心丸组LVESP,LV±dp/dtmax显著增加(P<0.05或P<0.01),LVEDP显著下降(P<0.05或P<0.01),TNF-α,IL-6含量显著降低(P<0.05或P<0.01)。结论:麝香保心丸能改善模型大鼠AMI后血流动力学参数,并减少梗死组织中炎性因子的释放,这可能是其改善心室重构的机制之一。
Objective: To observe the effect of Shexiang Baoxin Pill on the hemodynamic parameters and infarct inflammatory factor after acute myocardial infarction (AMI) in rats, and to explore its mechanism of improving ventricular remodeling after AMI. Methods: Left anterior descending coronary artery was ligated into AMI model. Seventy SD male rats were randomly divided into blank group, sham operation group, model group, low dose of Shexiang Baoxin Pill (14 mg.kg-1.d -1), high dose group of Shexiang Baoxin Pill (28 mg.kg-1.d-1) and simvastatin group (2 mg.kg-1.d-1). After two weeks of continuous ig, the hemodynamics of the rats in each group were measured, and the levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) RESULTS: Compared with the blank group, the LVESP, LV + dp / dtmax and LV-dp / dtmax of the model group were significantly decreased (P < (P <0.01), LVEDP increased significantly (P <0.01), TNF-α and IL-6 levels increased significantly (P <0.01). Compared with model group, LV ± dp / dtmax increased significantly (P <0.05 or P <0.01), LVEDP decreased significantly (P <0.05 or P <0.01), but TNF-α and IL-6 decreased significantly (P <0.05 or P <0.01). Conclusion: Shexiang Baoxin Pill can ameliorate the hemodynamic parameters after AMI in model rats and reduce the release of inflammatory cytokines in infarcted tissues, which may be one of the mechanisms to improve ventricular remodeling.