本文报告了偏食和过量氟化物对实验大鼠软骨基质成分胶原代谢的影响。过量NaF,引起大鼠肋软骨基质中可溶性胶原、胶原α_1(Ⅱ)链的分子量、软骨组织中单胺氧化酶活性均明显降低,尿中羟脯氨酸排泄量增加。单纯偏食对上述指标无明显影响,偏食同时给予过量NaF,则上述指标出现明显变化,表明在氟中毒发生发展过程中营养因素十分重要。提示避免偏食或增加营养会降低氟的毒性作用。 This article reports the effect of partial eclipse and excessive fluoride on the collagen metabolism of cartilage matrix in rats. Excess NaF caused the soluble collagen, the molecular weight of collagen α_1 (Ⅱ) chain and monoamine oxidase activity in cartilage tissue of rat costal cartilage matrix to increase, while the urinary hydroxyproline excretion increased. Simple partial eclipse had no significant effect on these indicators, partial eclipse while giving excessive NaF, the above indicators showed significant changes, indicating that the occurrence and development of fluoride poisoning in the development of nutritional factors is very important. Tips to avoid partial eclipse or increase nutrition will reduce the toxic effects of fluorine.