药物性肝炎的性质与特点所有抗结核药物都可能引起人体肝脏损伤或肝炎。肝脏为药物代谢的主要器官,多数药物都是通过在肝脏内氧化、还原、水解、结合反应等起到转化或解毒作用。有的直接对肝脏有毒性,直接损伤肝细胞。有的具有间接肝毒性,通过药物的中间代谢产物损伤肝细胞还有的药物通过免疫反应,使肝脏成为细胞免疫反应或体液抗体作用的器官及抗体原复合物沉积的部位,从而损伤肝脏。其他器官有药物反应时,有时肝脏也可受到毒性分解产物的继 The nature and characteristics of drug-induced hepatitis All anti-TB drugs may cause liver damage or hepatitis in humans. The liver is the main organ for drug metabolism. Most drugs convert or detoxify them by oxidation, reduction, hydrolysis, and binding reactions in the liver. Some are directly toxic to the liver, direct damage to the liver cells. Some have indirect hepatotoxicity, drugs through the drug’s intermediate metabolites damage liver cells and other drugs through the immune response, the liver becomes a cellular immune response or humoral antibody organs and antigen complex deposition site, thus damaging the liver. Other organs have drug reactions, and sometimes the liver can also be followed by toxic decomposition products