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目的观察纳络酮对血浆内皮素、血液流变学及海马神经原坏死的影响。方法通过大鼠脑损伤模型，测定血浆和海马内皮素、血液流变学指标及海马神经原坏死数。结果脑损伤组血浆、海马内皮素水平、全血粘度、红细胞聚集指数、血浆纤维蛋白原含量及Ｃａｓｓｏｎ屈服值均明显升高，海马神经原坏死数也明显增加；经纳络酮治疗后上述指标均明显下降，海马神经原坏死数也明显减少。结论纳络酮可通过改善血液流变学特性和降低内皮素水平来保护海马神经原，并对继发性脑损害起到治疗作用。
Objective To observe the effects of naloxone on plasma endothelin, hemorrheology and hippocampal neuron necrosis. Methods Rat brain injury model was used to determine plasma and hippocampal ET, hemorheological indexes and neuronal necrosis of hippocampus. Results The plasma and hippocampal levels of endothelin, whole blood viscosity, erythrocyte aggregation index, plasma fibrinogen content and Casson yield were significantly increased and the number of neuron necrosis in hippocampus in brain injury group was also significantly increased. After naloxone treatment, Were significantly decreased, the number of neurons in the hippocampus also significantly reduced. Conclusion Naloxone protects hippocampal neurons by improving hemorheological properties and decreasing endothelin levels, and plays a therapeutic role in secondary brain damage.