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干扰素(IFN)已广泛用于治疗慢性丙型肝炎,尽管治疗前低水平的丙肝病毒血症是干扰素治疗安全有效的前提之一,然而,某些病例在干扰素治疗前,尽管存在低浓度的丙肝病毒血症,仍未提示有血清转氨酶(ALT)浓度的改善.因此作者假设,丙肝病毒亚型可能会影响干扰素的抗病毒效果.在本研究中,作者对干扰素治疗慢性丙型肝炎患者的血清丙型肝炎病毒的核糖核酸(HCV一RNA)滴度进行定量分析,并确定其亚型,研究了血清ALT对这些因素之间的不同反应.146例慢性丙型肝炎患者(男/女比=107:39);平均年龄=46.3±12.4岁),接受人体β—干扰素治疗.全部病员血ALT浓度升高半年以上,肝活检证实有慢性肝炎,并排除了肝硬化症.根据血清学分析,无其他嗜肝病毒(A,B型肝炎,EB病毒和巨细胞病毒)的感染.无服药物、饮酒或自身免疫性疾病史.静脉滴注β—干扰素3—9mu/天;并8周(63例3mu/天;60例了6mu/天;23例9mu/天).治疗结束后半年,52例(20例3mu/天,27例6mu/天,5例9mu/天)提示血ALT维持正常连续半年以上,认为完全有效.55例(29例3mu/天,14例6mu/天,12例9mu/天)血ALT不正常,考虑为无效.为了评估血ALT与血HCV—RNA和HCV亚型之间的关系,随机选择52例完全有效者和55例无效者中的26例.治疗期间均每两月检查一次持续至治疗结束后至少半年.共抽取4次?
Interferon (IFN) has been widely used in the treatment of chronic hepatitis C, although pre-treatment low levels of hepatitis C viremia is one of the prerequisites for the safe and effective treatment of interferon. However, in some cases before interferon treatment, Concentration of hepatitis C viremia has not yet prompted the improvement of serum aminotransferase (ALT) concentration, so the authors hypothesize that hepatitis C virus subtypes may affect the antiviral effect of interferon.In this study, the authors of interferon treatment of chronic C Hepatitis C virus (HCV-RNA) titers were quantitatively analyzed and their subtypes were determined, and the different responses of serum ALT to these factors were studied.146 patients with chronic hepatitis C Male / female ratio = 107: 39); mean age = 46.3 ± 12.4 years) received human interferon-beta treatment.All patients’ blood ALT levels increased more than six months, liver biopsy confirmed chronic hepatitis and excluded cirrhosis. No other infections with Hepatitis B virus (Hepatitis A, B, Epstein-Barr virus and Cytomegalovirus) based on serological analysis Undetermined drug, alcohol or autoimmune disease history Intravenous infusion of interferon beta 3-9mu / Day; and 8 weeks (63 cases of 3mu / day; 60 cases of 6mu / Day and 23 cases of 9mu / day) .There were 52 cases (20 cases of 3mu / day, 27 cases of 6mu / day and 5 cases of 9mu / day) which showed that the blood ALT remained normal for more than half a year, (29 cases of 3mu / day, 14 cases of 6mu / day, 12 cases of 9mu / day) were considered as ineffective. To assess the relationship between blood ALT and blood HCV-RNA and HCV subtypes, 52 patients Completely effective and 55 ineffective in 26 cases during the treatment period are checked once every two months until the end of treatment at least six months a total of four times taken?