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本文报导三例在广州及江西发现的异常血红蛋白 HbQ 的研究结果。三例先证者均因贫血而住院治疗。血液学分析及家系调查结果表明,其中两例为 HbQ 与α地中海贫血双重杂合子(HbQ+H),贫血原因是由于 HbH 病所违成。经一级结构研究,证实三例异常 Hb 是α链第74或75残基 Asp→His,亦即 H1)。Taichung 或 Hb Iran。
This article reports the findings of three cases of abnormal hemoglobin HbQ found in Guangzhou and Jiangxi. Three cases of proband were hospitalized for anemia. Hematological analysis and pedigree investigation showed that two of them were HbQ + H heterozygote (HbQ + H), the cause of anemia was due to HbH disease. The primary structure of the study confirmed that three cases of abnormal Hb is the 74th or 75th residue in the α chain Asp → His, ie H1). Taichung or Hb Iran.