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胃复安是一种强力的特异性垂体前叶、肾上腺和肾脏水平多巴胺能活性的抑制剂,可致血浆催乳素、醛固酮和肾素活性增加,对血管加压素(AVP)分泌亦有作用。作者对后一种作用进行研究。 7名正常男性经静脉注射胃复安10mg后15min,血浆AVP(pAVP)从0.71±0.12pg/m1(±SE)升至1.28±0.24pg/ml(P<0.005),增加80.3%;然后下降,第90和第120min时pAVP出现第二峰(P值分别<0.05和<0.01),但血浆渗透压不变。
Metoclopramide is a potent, specific inhibitor of dopaminergic activity at the anterior pituitary, adrenal and renal levels that results in increased plasma prolactin, aldosterone, and renin activity, as well as an effect on vasopressin (AVP) secretion . The author studies the latter role. The plasma AVP (pAVP) increased by 80.3% from 0.71 ± 0.12 pg / ml (± SE) to 1.28 ± 0.24 pg / ml (P <0.005) by 80.3% after intravenous metoclopramide 10 mg intravenously in 7 normal men and then decreased , The second peak of pAVP appeared at the 90th and the 120th minute (P <0.05 and <0.01, respectively), but the plasma osmolality did not change.