溶血尿毒综合征(HUS),以急性微血管病性溶血性贫血、血小板减少和肾功能衰竭为其临床特征。病理学所见:在肾小球毛细血管及毛细血管前小动脉内有血小板和纤维蛋白所构成的血管内血栓,凝血有关检查通常显示血小板寿命缩短,而纤维蛋白原转换时间(Fibrinogen turnover)正常。本综合征1955年首先由Gasser等描述,以后世界各地均有报道,近年来有增多趋势,可能与对本征认识的不断提高有关。本征在临床上与血栓性血小板减少性紫癜(TTP)有许多相似之处,两者均属血栓性微血管病(Thrombotic mieroangiopathy,TMA)范畴。其病因尚未明了,但广泛性血管内血小板凝聚已被认为对本征的发病起决定性作用。Defreyn等认为HUS与TTP之不同主要是后者的病变累及肾脏 Hemolytic uremic syndrome (HUS), with acute microangiopathic hemolytic anemia, thrombocytopenia and renal failure as its clinical features. Pathological findings: in the glomerular capillary and pre-capillary arterioles with platelets and fibrin in the formation of intravascular thrombus, coagulation-related tests usually show shorter platelet life expectancy, and fibrinogen turnover time (Fibrinogen turnover) is normal . The Syndrome was first described by Gasser et al in 1955 and later reported in all parts of the world. In recent years, there is an increasing trend, which may be related to the continuous improvement of the intrinsic awareness. Intrinsic There are many similarities with thrombotic thrombocytopenic purpura (TTP) clinically, both of which are in the category of Thrombotic Mieroangiopathy (TMA). The etiology is not known, but extensive intravascular platelet aggregation has been considered to play a decisive role in the pathogenesis of the disease. Defreyn so that the difference between HUS and TTP is mainly the latter involving the kidney lesions